The historic town of Lexington, South Carolina is a direct descendent of the old Royal township of Saxe Gotha. This township was one of eleven established in 1735 by the Colonial government of King George II to encourage settlement of backcountry South Carolina and serve as a protective buffer between powerful Indian tribes to the west and the older settled plantations of the low country. The name Saxe Gotha was in honor of the marriage of the British Prince of Wales to Princess Augusta of the German State of Saxe Gotha.

The territory of colonial Saxe Gotha covered most of present day Lexington County and was traversed by two important early Indian trails, the Cherokee Path which followed roughly modern U.S. Highway #378 and the Occaneechi Path, today U.S. Highway #1. These ancient trading paths and the highways that later developed from them have had an enormous impact on the historical development of the area.

Most of the early settlers came from various cantons, principalities and city-states of Germany and Switzerland. Others came down from Pennsylvania, and Virginia. Despite the disruptive Cherokee Indian War of 1760 and the "Regulator" unrest that followed, the township flourished as a largely self-sufficient area of small scale farming operations. Major crops in the 18 th Century included corn, wheat, tobacco, hemp, flax, beeswax and livestock.