The San Bernardino History and Railroad Museum opened its doors to the public on July 12, 2008.  It is located in the San Bernardino train depot in the former Santa Fe Baggage Room and Railroad Express Agency Room.

The museum is a joint operation of two 501(c)(3) not-for-profit organizations: the San Bernardino Historical and Pioneer Society, and the San Bernardino Railroad Historical Society (operators of Santa Fe Steam Engine 3751).

Within the museum, the Santa Fe Railway Historical and Modeling Society (SFRH&MS) maintains the Western Archives of the Santa Fe Railroad.

All facets of the museum are conducted by volunteers, as there are no paid employees.