The Opelousas Museum and Interpretive Center is a general history museum dedicated to collecting, preserving, and interpreting those objects and artifacts which provide information about the history and culture of the Opelousas area from prehistoric times to the present.

Exhibits cover prehistory, agriculture, home and family, business and professions, music, food and a Hall of Fame.  One room is dedicated to the Civil War, and two other rooms house the Geraldine Smith Welch Doll Collection of over 400 dolls.  The museum is also home to the Louisiana Video Collection Library and the Southwest Louisiana Zydeco Music Festival Archives